反应详情

Compound 3 is prepared according to synthesis method 2: 0.4 g (2.42 mmoles) of derivative 5a is placed in 10 ml of CH2Cl2. 0.5 ml (3.63 mmoles) of triethylamine is added. At 0° C., 0.4 ml (2.66 mmoles) of trifluoromethylbenzoyl chloride is added drop by drop, the reaction medium is stirred at ambient temperature for 18 hours. After concentrating the reaction medium to dryness, the residue obtained is taken up with AcOEt and washed with water. After drying on MgSO4, the organic phase is concentrated. The residue obtained is purified by silica flash chromatography (CH2Cl2,100%). 0.72 g of yellow powder is isolated (yield: 95%).

1. customaccording to synthesis method 2
2. concentrationAfter concentrating the reaction medium to dryness
3. customthe residue obtained
4. washwashed with water
5. customAfter drying on MgSO4
6. concentrationthe organic phase is concentrated
7. customThe residue obtained
8. customis purified by silica flash chromatography (CH2Cl2,100%)