HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 53493384, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 2-(Trifluoromethyl)benzoyl chloride | HCID 67561 | — |
| Reactant | 3-(Piperazin-1-yl)-1,2,4-triazine | HCID 12296696 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 53493384 | HCID 53493384 | 95% |
Reaction Steps
Compound 3 is prepared according to synthesis method 2: 0.4 g (2.42 mmoles) of derivative 5a is placed in 10 ml of CH2Cl2. 0.5 ml (3.63 mmoles) of triethylamine is added. At 0° C., 0.4 ml (2.66 mmoles) of trifluoromethylbenzoyl chloride is added drop by drop, the reaction medium is stirred at ambient temperature for 18 hours. After concentrating the reaction medium to dryness, the residue obtained is taken up with AcOEt and washed with water. After drying on MgSO4, the organic phase is concentrated. The residue obtained is purified by silica flash chromatography (CH2Cl2,100%). 0.72 g of yellow powder is isolated (yield: 95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962837B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-442549949af141279dab38c84a19b011 |
| Source note | uspto-grants-2015_02 |