1-(Bromomethyl)-2-(trifluoromethyl)benzene → Toluene

HRID 1854814Notes

Reaction equation

HRID 1854814 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]([F:12])([F:11])[F:10].[N:13]1([C:19]2[N:20]=[N:21][CH:22]=[CH:23][N:24]=2)[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>>[F:10][C:9]([F:12])([F:11])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[CH2:2][N:16]1[CH2:15][CH2:14][N:13]([C:19]2[N:20]=[N:21][CH:22]=[CH:23][N:24]=2)[CH2:18][CH2:17]1.[C:3]1([CH3:2])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 1230571-(Bromomethyl)-2-(trifluoromethyl)benzeneHCID 12296696HCID 12296696, compound

Product 2

HCID 1140TolueneYield 33%HCID 53493508HCID 53493508, compound

Procedure

Compound 5 is prepared from 1-bromomethyl-2-trifluoromethyl-benzene and intermediate 5a according to synthesis method 2 in refluxing toluene (33% yield).

Workup

  1. customaccording to synthesis method 2

Sources & evidence

ORD record
ord-4b0b56fce1b14a60b311f2a446477f7a
Source dataset
uspto-grants-2015_02
Patent number
US08962837B2

Reaction notes

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