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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1854814Generated: November 2, 2026

1-(Bromomethyl)-2-(trifluoromethyl)benzene → Toluene

https://huagongshe.com/reaction/1854814

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bromomethyl)-2-(trifluoromethyl)benzeneHCID 123057—
Reactant3-(Piperazin-1-yl)-1,2,4-triazineHCID 12296696—
ProductTolueneHCID 114033%
ProductHCID 53493508HCID 53493508—

Reaction Steps

Compound 5 is prepared from 1-bromomethyl-2-trifluoromethyl-benzene and intermediate 5a according to synthesis method 2 in refluxing toluene (33% yield).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08962837B2
Source datasetuspto-grants-2015_02
ORD IDord-4b0b56fce1b14a60b311f2a446477f7a
Source noteuspto-grants-2015_02