反应详情

温度

112.5 °C

To a solution of 1-(2,3-Difluorophenyl)-2-(1-(trityloxy)but-3-en-2-yloxy)ethanone oxime 16 (20.0 g, 0.0400 mol, 1.0 equiv.) in toluene (140 mL) was charged hydroquinone (0.0882 g, 0.008 mol, 0.2 equiv.). The reaction mixture was heated to reflux (110-115° C.) and held for 13 hours. The reaction mixture was cooled to 20-25° C. and then concentrated under vacuum (T<45° C.). The solvents were chased with 2-propanol (100 mL). To the crude residue was charged isopropanol (140 mL) and the mixture was heated to 65-70° C. until a clear solution is formed. The solution was cooled to 0° C. at 10° C./hr and then held for 1 hour. The resulting suspension was filtered and the solid was rinsed with cold 2-propanol (40.0). After drying the title compound 17 was obtained as a powder (13.2 g).

1. temperatureThe reaction mixture was heated
2. temperatureThe reaction mixture was cooled to 20-25° C.
3. concentrationconcentrated under vacuum (T<45° C.)
4. additionTo the crude residue was charged isopropanol (140 mL)
5. temperaturethe mixture was heated to 65-70° C. until a clear solution
6. customis formed
7. temperatureThe solution was cooled to 0° C. at 10° C./hr
8. waitheld for 1 hour
9. filtrationThe resulting suspension was filtered
10. washthe solid was rinsed with cold 2-propanol (40.0)
11. dry with materialAfter drying the title compound 17