4-Aminophenol → Benzenesulfonamide, N-(4-hydroxyphenyl)-

HRID 1855317Notes

Reaction equation

HRID 1855317 reaction equation
[CH:1]1[C:6]([NH2:7])=[CH:5][CH:4]=[C:3]([OH:8])[CH:2]=1.[C:9]1([S:15](Cl)(=[O:17])=[O:16])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>N1C=CC=CC=1>[C:9]1([S:15]([NH:7][C:6]2[CH:5]=[CH:4][C:3]([OH:8])=[CH:2][CH:1]=2)(=[O:17])=[O:16])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 4034-AminophenolHCID 7369Benzenesulfonyl chloride

Product 1

HCID 79622Benzenesulfonamide, N-(4-hydroxyphenyl)-Yield 59.4%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The same procedure as above (Example 1) is followed, starting with 10.9 g (0.1 mol) of p-aminophenol in 40 ml of anhydrous pyridine and 18 g (1 equivalent) of benzenesulfonyl chloride. 14.8 g of p-benzenesulfonamidophenol are obtained.

Sources & evidence

ORD record
ord-be68d113a5f54c0c81b264a92e1c594a
Source dataset
uspto-grants-2015_02
Patent number
US08962869B2

Reaction notes

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