Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate → HCID 57829726, compound

HRID 1855356Notes

Reaction equation

HRID 1855356 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:15])[CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]1.Cl[C:17]1[N:22]=[C:21]([C:23]([F:26])([F:25])[F:24])[C:20]([C:27]([O:29][CH3:30])=[O:28])=[CH:19][N:18]=1>>[CH3:30][O:29][C:27]([C:20]1[C:21]([C:23]([F:26])([F:24])[F:25])=[N:22][C:17]([NH:15][C:5]2[CH:6]=[CH:7][C:8]([N:9]3[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]3)=[C:3]([O:2][CH3:1])[CH:4]=2)=[N:18][CH:19]=1)=[O:28]

Participants

3

Reactant 2

HCID 3696469Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylateHCID 454801813-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline

Product 1

HCID 57829726HCID 57829726, compound

Procedure

The title compound was prepared in analogous manner as described in example 1e) from 3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamine and methyl 2-chloro-4-trifluoromethyl-pyrimidine-5-carboxylate. The reaction was heated to reflux for 16 h. The title compound was obtained as a pale-yellow solid in 20% yield.

Workup

  1. customThe title compound was prepared in analogous manner
  2. temperatureThe reaction was heated
  3. temperatureto reflux for 16 h

Sources & evidence

ORD record
ord-094217d71e0f49a7b7da80930b1c0310
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

Loading…