HCID 68631884, compound → HCID 57829811, compound

HRID 1855366Notes

Reaction equation

HRID 1855366 reaction equation
CN(C)[CH:3]=[C:4]([C:10](=O)[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]#[N:18])[CH:12]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6].[N+]([O-])(O)=O.[N+]([O-])(O)=O.[CH3:29][O:30][C:31]1[CH:32]=[C:33]([NH:43][C:44]([NH2:46])=[NH:45])[CH:34]=[CH:35][C:36]=1[N:37]1[CH:41]=[C:40]([CH3:42])[N:39]=[CH:38]1>>[C:17]([C:13]1[CH:12]=[C:11]([C:10]2[C:4]([C:5]([O:7][CH2:8][CH3:9])=[O:6])=[CH:3][N:46]=[C:44]([NH:43][C:33]3[CH:34]=[CH:35][C:36]([N:37]4[CH:41]=[C:40]([CH3:42])[N:39]=[CH:38]4)=[C:31]([O:30][CH3:29])[CH:32]=3)[N:45]=2)[CH:16]=[CH:15][CH:14]=1)#[N:18]

Participants

3

Reactant 2

HCID 68631884HCID 68631884, compoundHCID 178493228HCID 178493228, compound

Product 1

HCID 57829811HCID 57829811, compound

Procedure

The title compound was prepared from ethyl 3-dimethylamino-2-(3-cyano-benzoyl)-acrylate (85 mg, 0.31 mmol) and N-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-guanidine dinitrate (116 mg, 0.31 mmol) using in analogous manner the procedure described in example 28b). Obtained as a pale-yellow solid (41 mg, 29%). Mp 195-197° C.

Sources & evidence

ORD record
ord-8e54135ec4e7442ba152f99d5e093751
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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