HCID 54104092, compound → Ethyl 4-(4-chloro-phenyl)-2-[3-fluoro-4-(4-methyl-imidazol-1-yl)-phenylamino]-pyrimidine-5-carboxylate

HRID 1855369Notes

Reaction equation

HRID 1855369 reaction equation
CN(C)[CH:3]=[C:4]([C:10](=O)[C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6].[N+]([O-])(O)=O.[N+]([O-])(O)=O.[F:28][C:29]1[CH:30]=[C:31]([NH:41][C:42]([NH2:44])=[NH:43])[CH:32]=[CH:33][C:34]=1[N:35]1[CH:39]=[C:38]([CH3:40])[N:37]=[CH:36]1>>[Cl:17][C:14]1[CH:13]=[CH:12][C:11]([C:10]2[C:4]([C:5]([O:7][CH2:8][CH3:9])=[O:6])=[CH:3][N:44]=[C:42]([NH:41][C:31]3[CH:32]=[CH:33][C:34]([N:35]4[CH:39]=[C:38]([CH3:40])[N:37]=[CH:36]4)=[C:29]([F:28])[CH:30]=3)[N:43]=2)=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 54104092HCID 54104092, compoundHCID 178429955HCID 178429955, compound

Product 1

HCID 57829829Ethyl 4-(4-chloro-phenyl)-2-[3-fluoro-4-(4-methyl-imidazol-1-yl)-phenylamino]-pyrimidine-5-carboxylate

Procedure

The title compound was prepared from crude ethyl 3-dimethylamino-2-(4-chloro-benzoyl)-acrylate (89 mg, 0.3 mmol) and N-[3-fluoro-4-(4-methyl-imidazol-1-yl)-phenyl]-guanidine dinitrate (80 mg, 0.22 mmol) using in analogous manner the procedure described in example 28b). Obtained as a pale-yellow solid (28 mg, 28%). Mp 232-234° C.

Sources & evidence

ORD record
ord-31fa3559825e41048c55874e973247d4
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

Loading…