4-Benzyl-2-chloro-pyrimidine → (4-Benzyl-pyrimidin-2-yl)-[3-fluoro-4-(4-methyl-imidazol-1-yl)-phenyl]-amine

HRID 1855378Notes

Reaction equation

HRID 1855378 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH2:14])[CH:5]=[CH:6][C:7]=1[N:8]1[CH:12]=[C:11]([CH3:13])[N:10]=[CH:9]1.[CH2:15]([C:22]1[CH:27]=[CH:26][N:25]=[C:24](Cl)[N:23]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH2:15]([C:22]1[CH:27]=[CH:26][N:25]=[C:24]([NH:14][C:4]2[CH:5]=[CH:6][C:7]([N:8]3[CH:12]=[C:11]([CH3:13])[N:10]=[CH:9]3)=[C:2]([F:1])[CH:3]=2)[N:23]=1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 183533314-Benzyl-2-chloro-pyrimidineHCID 218766383-Fluoro-4-(4-methyl-1H-imidazol-1-yl)aniline

Product 1

HCID 57829814(4-Benzyl-pyrimidin-2-yl)-[3-fluoro-4-(4-methyl-imidazol-1-yl)-phenyl]-amine

Procedure

The title compound was prepared from 3-fluoro-4-(4-methyl-imidazol-1-yl)-phenylamine (94 mg, 0.49 mmol) and 4-benzyl-2-chloro-pyrimidine (100 mg, 0.49 mmol) in analogous manner to the procedure described in example 1e). Obtained as a pale-yellow solid (50 mg, 29%).

Sources & evidence

ORD record
ord-115b1237ad7d46588d56d91047ebfddf
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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