3-fluoro-4-(1H-1,2,4-triazol-1-yl)aniline → (4-Benzyl-6-methyl-pyrimidin-2-yl)-(3-fluoro-4-[1,2,4]triazol-1-yl-phenyl)-amine

HRID 1855381Notes

Reaction equation

HRID 1855381 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH2:13])[CH:5]=[CH:6][C:7]=1[N:8]1[CH:12]=[N:11][CH:10]=[N:9]1.[CH2:14]([C:21]1[CH:26]=[C:25]([CH3:27])[N:24]=[C:23](Cl)[N:22]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH2:14]([C:21]1[CH:26]=[C:25]([CH3:27])[N:24]=[C:23]([NH:13][C:4]2[CH:5]=[CH:6][C:7]([N:8]3[CH:12]=[N:11][CH:10]=[N:9]3)=[C:2]([F:1])[CH:3]=2)[N:22]=1)[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 223295463-fluoro-4-(1H-1,2,4-triazol-1-yl)anilineHCID 866336184-Benzyl-2-chloro-6-methyl-pyrimidine

Product 1

HCID 57829862(4-Benzyl-6-methyl-pyrimidin-2-yl)-(3-fluoro-4-[1,2,4]triazol-1-yl-phenyl)-amine

Procedure

The title compound was prepared from 3-fluoro-4-[1,2,4]triazol-1-yl-phenylamine (81.4 mg, 0.46 mmol) and 4-benzyl-2-chloro-6-methyl-pyrimidine (100 mg, 0.46 mmol) in analogous manner to the procedure described in example 1e). Obtained as a light yellow wax (98 mg, 60%).

Workup

  1. customObtained as a light yellow wax (98 mg, 60%)

Sources & evidence

ORD record
ord-c80720a1e17040bd9d1e12090bf804b2
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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