(2,6-Dichloropyridin-4-yl)methanol → HCID 57829746, compound

HRID 1855407Notes

Reaction equation

HRID 1855407 reaction equation
Cl[C:2]1[CH:7]=[C:6]([CH2:8][OH:9])[CH:5]=[C:4]([Cl:10])[N:3]=1.[CH3:11][O:12][C:13]1[CH:14]=[C:15]([NH2:25])[CH:16]=[CH:17][C:18]=1[N:19]1[CH:23]=[C:22]([CH3:24])[N:21]=[CH:20]1>>[Cl:10][C:4]1[CH:5]=[C:6]([CH2:8][OH:9])[CH:7]=[C:2]([NH:25][C:15]2[CH:16]=[CH:17][C:18]([N:19]3[CH:23]=[C:22]([CH3:24])[N:21]=[CH:20]3)=[C:13]([O:12][CH3:11])[CH:14]=2)[N:3]=1

Participants

3

Reactant 2

HCID 2794840(2,6-Dichloropyridin-4-yl)methanolHCID 454801813-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline

Product 1

HCID 57829746HCID 57829746, compound

Procedure

The title compound was prepared in analogous manner as described in example 1e) from 2,6-dichloropyridin-4-methanol (53 mg, 0.3 mmol) and 3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamine (61 mg, 0.3 mmol). The reaction was heated for 16 h to reflux. Obtained as a pale-yellow solid (25 mg, 24%) after column chromatography on silica gel using dichloromethane/methanol (9:1 v/v) as eluent.

Workup

  1. temperatureThe reaction was heated for 16 h
  2. temperatureto reflux

Sources & evidence

ORD record
ord-6418f837f0bc4cc7ab82440edf16c495
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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