Potassium Carbonate → HCID 57829845, compound

HRID 1855426Notes

Reaction equation

HRID 1855426 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:15])[CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]1.Cl[C:17]1[N:22]=[C:21]([O:23][CH3:24])[CH:20]=[C:19]([O:25][CH3:26])[N:18]=1.C(=O)([O-])[O-].[K+].[K+]>>[CH3:26][O:25][C:19]1[CH:20]=[C:21]([O:23][CH3:24])[N:22]=[C:17]([NH:15][C:5]2[CH:6]=[CH:7][C:8]([N:9]3[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]3)=[C:3]([O:2][CH3:1])[CH:4]=2)[N:18]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 51523232-Chloro-4,6-dimethoxypyrimidineHCID 454801813-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline

Product 1

HCID 57829845HCID 57829845, compoundYield 52%

Procedure

Prepared in analogy to example 81b) from 3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamine and 2-chloro-4,6-dimethoxypyrimidine, using potassium carbonate as a base. The title compound was isolated in a yield of 52%. MS ISP (m/e): 342.1 (100) [(M+H)+]. 1H NMR (CDCl3, 300 MHz): δ (ppm)=7.70-7.55 (m broad, 2H), 7.35-7.20 (m broad, 3H), 7.04 (s broad, 1H), 3.92 (s broad, 6H), 3.81 (s broad, 3H), 2.14 (s broad, 3H).

Sources & evidence

ORD record
ord-fdfa189bb1484ea18c2027b62598f2dc
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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