2,4-Dichloro-6-methylpyrimidine → HCID 86633625, compound

HRID 1855443Notes

Reaction equation

HRID 1855443 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([CH3:9])[N:3]=1.Cl.[C:11]([O:15][C:16](=[O:20])[CH2:17][NH:18][CH3:19])([CH3:14])([CH3:13])[CH3:12]>>[C:11]([O:15][C:16](=[O:20])[CH2:17][N:18]([C:6]1[CH:5]=[C:4]([CH3:9])[N:3]=[C:2]([Cl:1])[N:7]=1)[CH3:19])([CH3:14])([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 794712,4-Dichloro-6-methylpyrimidineHCID 11252350Sarcosine t-butyl ester hydrochloride

Product 1

HCID 86633625HCID 86633625, compoundYield 52%

Procedure

Prepared in analogy to example 98a), using 2,4-dichloro-6-methylpyrimidine and sarcosine tert-butyl ester hydrochloride. The title compound was isolated as a slightly yellow oil in a yield of 52%. MS ISP (m/e): 272.2 & 274.0 (25 & 10) [(M+H)+]. 1H NMR (CDCl3, 300 MHz): δ (ppm)=6.23 (s broad, 1H), 4.21 (s broad, 2H), 3.10 (s broad, 3H), 2.36 (s, 3H), 1.46 (s, 9H).

Workup

  1. customPrepared in analogy to example 98a),

Sources & evidence

ORD record
ord-41e8c918e0ba48d7a070faa2573db2fc
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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