2,4-Dichloro-6-methylpyrimidine → HCID 86633626, compound

HRID 1855445Notes

Reaction equation

HRID 1855445 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([CH3:9])[N:3]=1.Cl.[CH2:11]([O:18][C:19](=[O:23])[CH2:20][NH:21][CH3:22])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH2:11]([O:18][C:19](=[O:23])[CH2:20][N:21]([C:6]1[CH:5]=[C:4]([CH3:9])[N:3]=[C:2]([Cl:1])[N:7]=1)[CH3:22])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 794712,4-Dichloro-6-methylpyrimidineHCID 18618415Benzyl N-methylglycinate--hydrogen chloride (1/1)

Product 1

HCID 86633626HCID 86633626, compoundYield 62%

Procedure

Prepared in analogy to example 98a), using 2,4-dichloro-6-methylpyrimidine and sarcosine-benzylester hydrochloride. The title compound was isolated as a slightly yellow oil in a yield of 62%. MS ISP (m/e): 306.1 & 308.2 (100 & 38) [(M+H)+]. 1H NMR (CDCl3, 300 MHz): δ (ppm)=7.40-7.35 (m, 5H), 6.23 (s broad, 1H), 5.19 (s, 2H), 4.39 (s broad, 2H), 3.11 (s broad, 3H), 2.36 (s, 3H).

Workup

  1. customPrepared in analogy to example 98a),

Sources & evidence

ORD record
ord-c0dcb271383a47aa9add9084d2ee8c5a
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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