2,4-Dichloro-6-methylpyrimidine → HCID 86633627, compound

HRID 1855452Notes

Reaction equation

HRID 1855452 reaction equation
Cl[C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([CH3:9])[N:3]=1.[CH3:10][S:11]([N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1)(=[O:13])=[O:12]>>[Cl:8][C:6]1[CH:5]=[C:4]([CH3:9])[N:3]=[C:2]([N:17]2[CH2:18][CH2:19][N:14]([S:11]([CH3:10])(=[O:13])=[O:12])[CH2:15][CH2:16]2)[N:7]=1

Participants

3

Reactant 2

HCID 794712,4-Dichloro-6-methylpyrimidineHCID 7091611-(Methylsulfonyl)piperazine

Product 1

HCID 86633627HCID 86633627, compoundYield 41%

Procedure

Prepared in analogy to example 98a), using 2,4-dichloro-6-methylpyrimidine and 1-methanesulfonyl-piperazine. The title compound was isolated as a yellow solid in a yield of 41%. MS ISP (m/e): 291.1 (100) [(M+H)+]. 1H NMR (DMSO-D6, 300 MHz): δ (ppm)=6.81 (s, 1H), 3.80-3.70 (m, 4H), 3.20-3.15 (m, 4H), 2.90 (s, 3H), 2.26 (s, 3H).

Workup

  1. customPrepared in analogy to example 98a),

Sources & evidence

ORD record
ord-cd01968456fe4c97b75f54dcbc8a0faf
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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