4-(Pyridin-4-yl)aniline → HCID 57829745, compound

HRID 1855512Notes

Reaction equation

HRID 1855512 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:13]=[CH:12][C:10]([NH2:11])=[CH:9][CH:8]=2)=[CH:3][CH:2]=1.[CH2:14]([C:21]1[CH:26]=[C:25]([CH3:27])[N:24]=[C:23](Cl)[N:22]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH2:14]([C:21]1[CH:26]=[C:25]([CH3:27])[N:24]=[C:23]([NH:11][C:10]2[CH:12]=[CH:13][C:7]([C:4]3[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=3)=[CH:8][CH:9]=2)[N:22]=1)[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 15126544-(Pyridin-4-yl)anilineHCID 866336184-Benzyl-2-chloro-6-methyl-pyrimidine

Product 1

HCID 57829745HCID 57829745, compound

Procedure

Prepared in analogy to example 62 from 4-(pyridin-4-yl) aniline and 4-benzyl-2-chloro-6-methyl-pyrimidine (example 43a). The title compound was obtained as a brownish oil (Yield=31%). MS ISP (m/e): 353.1 (100) [(M+H)+]. 1H NMR (DMSO-D6, 300 MHz): δ (ppm)=9.80 (s, 1H), 8.57 (d, 2H), 7.95 (d, 2H), 7.74 (d, 2H), 7.69 (d, 2H), 7.40-7.15 (m, 5H), 6.68 (s, 1H), 3.95 (s, 2H), 2.34 (s, 3H).

Sources & evidence

ORD record
ord-1357daf20c7f4e77966b55961173d4d2
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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