2-Chloro-4,6-dimethylpyrimidine → HCID 44192701, compound

HRID 1855537Notes

Reaction equation

HRID 1855537 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=2)[CH:5]=[CH:4][N:3]=1.Cl[C:16]1[N:21]=[C:20]([CH3:22])[CH:19]=[C:18]([CH3:23])[N:17]=1>>[CH3:23][C:18]1[CH:19]=[C:20]([CH3:22])[N:21]=[C:16]([NH:14][C:11]2[CH:12]=[CH:13][C:8]([C:6]3[CH:5]=[CH:4][N:3]=[C:2]([CH3:1])[CH:7]=3)=[CH:9][CH:10]=2)[N:17]=1

Participants

3

Reactant 2

HCID 205502-Chloro-4,6-dimethylpyrimidineHCID 20507215HCID 20507215, compound

Product 1

HCID 44192701HCID 44192701, compound

Procedure

The title compound was prepared in analogy to example 62 from 4-(2-methyl-pyridin-4-yl)-phenylamine and 2-chloro-4,6-dimethylpyrimidine. Obtained as a yellowish solid (Yield=33%). MS ISP (m/e): 291.1 (100) [(M+H)+]. 1H NMR (DMSO-D6, 300 MHz): δ (ppm)=9.73 (s, 1H), 8.43 (d, 1H), 7.97 (d, 2H), 7.73 (d, 2H), 7.55 (s, 1H); 7.47 (d, 1H), 6.67 (s, 1H), 2.50 (s, 3H hidden in DMSO-peak), 2.34 (s, 6H).

Sources & evidence

ORD record
ord-2edd761131514e2698e906d4cf67d159
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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