HCID 20507215, compound → HCID 44192793, compound

HRID 1855538Notes

Reaction equation

HRID 1855538 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=2)[CH:5]=[CH:4][N:3]=1.[CH2:15]([C:22]1[CH:27]=[C:26]([CH3:28])[N:25]=[C:24](Cl)[N:23]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH2:15]([C:22]1[CH:27]=[C:26]([CH3:28])[N:25]=[C:24]([NH:14][C:11]2[CH:12]=[CH:13][C:8]([C:6]3[CH:5]=[CH:4][N:3]=[C:2]([CH3:1])[CH:7]=3)=[CH:9][CH:10]=2)[N:23]=1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 20507215HCID 20507215, compoundHCID 866336184-Benzyl-2-chloro-6-methyl-pyrimidine

Product 1

HCID 44192793HCID 44192793, compound

Procedure

The title compound was prepared in analogy to example 62 from 4-(2-methyl-pyridin-4-yl)-phenylamine and 4-benzyl-2-chloro-6-methyl-pyrimidine (example 43a). Obtained as a yellowish solid (Yield=48%). MS ISP (m/e): 367.1 (100) [(M+H)+]. 1H NMR (DMSO-D6, 300 MHz): δ (ppm)=9.77 (s, 1H), 8.45 (d, 1H), 7.93 (d, 2H), 7.71 (d, 2H), 7.55 (s, 1H), 7.47 (d, 1H), 7.35-7.20 (m, 5H), 6.67 (s, 1H), 3.95 (s, 2H), 2.51 (s, 3H), 2.33 (s, 3H).

Sources & evidence

ORD record
ord-1a2fe6cda2d24134815559b58de8ff87
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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