Hydrochloric Acid → HCID 12520022, compound

HRID 1855724Notes

Reaction equation

HRID 1855724 reaction equation
[CH2:1]([O:3][C:4]1[C:5]([NH:9]C=O)=[CH:6][S:7][CH:8]=1)[CH3:2].Cl>C(O)C>[NH2:9][C:5]1[C:4]([O:3][CH2:1][CH3:2])=[CH:8][S:7][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12520017HCID 12520017, compound

Product 1

HCID 12520022HCID 12520022, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 15.4 g. of N-(4-ethoxy-3-thienyl)formamide in 50 ml. of 2 N ethanolic hydrogen chloride and 90 ml. of ethanol is refluxed on a steam bath for 2 hours, filtered and evaporated to a residue. Water is added to the residue, which is cooled, made alkaline with 5 N sodium hydroxide and extracted with dichloromethane. The extracts are dried over magnesium dulfate, filtered and evaporated giving 3-amino-4-ethoxythiophene as a dark amber oil.

Workup

  1. additionA mixture of 15.4 g
  2. filtrationfiltered
  3. customevaporated to a residue
  4. additionWater is added to the residue, which
  5. temperatureis cooled
  6. extractionextracted with dichloromethane
  7. dry with materialThe extracts are dried over magnesium dulfate
  8. filtrationfiltered
  9. customevaporated

Sources & evidence

ORD record
ord-eb78de9318eb4079a7c6f7d530721aa2
Source dataset
uspto-grants-1980_08
Patent number
US04216148

Reaction notes

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