HCID 12680125, compound → HCID 12482555, compound

HRID 1855726Notes

Reaction equation

HRID 1855726 reaction equation
[NH2:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[C:4]([NH:6][C:7]1[C:11](OCC)=[CH:10][S:9][CH:8]=1)=[O:5]>O>[CH:8]1[S:9][CH:10]=[C:11]2[C:7]=1[NH:6][C:4](=[O:5])[C:3]1[CH:15]=[CH:16][CH:17]=[CH:18][C:2]=1[NH:1]2

Participants

3

Reactant 1

HCID 12680125HCID 12680125, compound

Product 1

HCID 12482555HCID 12482555, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A 7.2 g. portion of the above benzamide in 100 g. of polyphosphoric acid is heated at 115°-125° C. for 2 hours, cooled, poured into ice and water and extracted with chloroform. The extract is washed with water, dried over magnesium sulfate, filtered and evaporated, giving 4H-thieno[3,4-b][1,4]benzodiazepin-9(10H)-one as a yellow solid.

Workup

  1. temperaturecooled
  2. extractionextracted with chloroform
  3. washThe extract is washed with water
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. customevaporated

Sources & evidence

ORD record
ord-dd9358afb2d14e33a40418ed78b94fc6
Source dataset
uspto-grants-1980_08
Patent number
US04216148

Reaction notes

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