Acetone → Atrolactic acid

HRID 1855752Notes

Reaction equation

HRID 1855752 reaction equation
C[C:2]1[CH2:7][CH2:6][CH2:5][C:4](C)(C)[C:3]=1/[CH:10]=[CH:11]/C(/C)=C/C=C/C(/C)=C/C(O)=O.C1(CC(O)[C:31]([OH:33])=[O:32])C=CC=CC=1.CC(C)=[O:37]>>[C:3]1([C:10]([CH3:11])([OH:37])[C:31]([OH:33])=[O:32])[CH:2]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 180AcetoneHCID 3848(+-)-3-Phenyllactic acidHCID 444795Retinoic Acid

Product 1

HCID 1303Atrolactic acid

Procedure

Retinoyl phenyl lactic acid 0.5 gm which is synthesized from all-trans-retinoic acid and beta-phenyl lactic acid, according to a modified method described in Example 1, is dissolved in 5 ml of acetone, and the solution admixed with 95 gm of hydrophilic ointment, USP. The mixing is continued until a uniform consistency is obtained.

Workup

  1. customis obtained

Sources & evidence

ORD record
ord-9469cfed63cc46b9b906d6bdaf604d34
Source dataset
uspto-grants-1980_08
Patent number
US04216224

Reaction notes

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