Phenylacetyl chloride → HCID 12837866, compound

HRID 1855756Notes

Reaction equation

HRID 1855756 reaction equation
[C:1]([NH:4][C:5](=[O:8])[CH2:6][SH:7])(=[O:3])[CH3:2].[C:9]1([CH2:15][C:16](Cl)=[O:17])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C(N(CC)CC)C>C(Cl)(Cl)Cl>[C:1]([NH:4][C:5](=[O:8])[CH2:6][S:7][C:16](=[O:17])[CH2:15][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 7679Phenylacetyl chlorideHCID 8471TriethylamineHCID 12837860HCID 12837860, compound

Product 1

HCID 12837866HCID 12837866, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To 0.10 mole of N-acetyl-2-mercapto acetamide in 150 ml. of chloroform is added 0.1 mole of phenyl acetylchloride followed by 0.1 mole of triethylamine. The reaction mixture is stirred at ambient temperature for 1 hour and then concentrated to dryness. Chromatograph of the residue on 500 g. of silica gel eluting with ethylacetate in hexane (25-75%) gives N-acetyl-2-(phenylacetylthio) acetamide.

Workup

  1. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-2161a14f6663422cb36ca5922cbe4c21
Source dataset
uspto-grants-1980_08
Patent number
US04216160

Reaction notes

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