HRID1855851

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13373525

未命名化合物

HCID19261392

未命名化合物

结构：S=c1[nH]c(NCCSCc2ncccc2Cl)ncc1Cc1cccnc1

HCID23349150

未命名化合物

PRODUCTS

生成物

HCID14338579

未命名化合物

结构：Cc1[nH]cnc1CSCCNc1ncc(OCc2cccnc2)c(=O)[nH]1

HCID23349282

未命名化合物

PROCEDURE

实验过程

Ethyl 3-pyridylmethoxyacetate is converted into 5-(3-pyridylmethoxy)-2-thiouracil by the general procedure of Example 1 (i). Substitution of 5-(3-pyridylmethoxy)-2-thiouracil for 5-(4-pyridylmethyl)-2-thiouracil in the general procedure of Example 1 gives 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(3-pyridylmethoxy)-4-pyrimidone.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9c148b54817249f8acd24873b858cfff
来源数据集: uspto-grants-1980_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04216318
来源说明: uspto-grants-1980_08

反应 SMILES

[N:1]1[CH:6]=[CH:5][CH:4]=[C:3](COCC(OCC)=O)[CH:2]=1.[N:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][O:22][C:23]2[C:24](=[O:30])[NH:25][C:26](=[S:29])[NH:27][CH:28]=2)[CH:16]=1.Cl[C:32]1[C:33]([CH2:38][S:39][CH2:40][CH2:41][NH:42][C:43]2NC(=S)[C:46](CC3C=NC=CC=3)=[CH:45][N:44]=2)=[N:34]C=CC=1>>[N:1]1[CH:2]=[CH:3][C:4]([CH2:32][C:23]2[C:24](=[O:30])[NH:25][C:26](=[S:29])[NH:27][CH:28]=2)=[CH:5][CH:6]=1.[CH3:46][C:45]1[NH:44][CH:43]=[N:42][C:41]=1[CH2:40][S:39][CH2:38][CH2:33][NH:34][C:26]1[NH:25][C:24](=[O:30])[C:23]([O:22][CH2:21][C:17]2[CH:16]=[N:15][CH:20]=[CH:19][CH:18]=2)=[CH:28][N:27]=1