HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(3-Pyridylmethoxy)-2-thiouracil → 5-(4-Pyridylmethyl)-2-thiouracil
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(3-Pyridylmethoxy)-2-thiouracil | HCID 13373525 | — |
| Reactant | Ethyl 2-((pyridin-3-yl)methoxy)acetate | HCID 19261392 | — |
| Reactant | 2-[2-(3-Chloro-2-pyridylmethylthio)ethylamino]-5-(3-pyridylmethyl)pyrimid-4-thione | HCID 23349150 | — |
| Product | 5-(4-Pyridylmethyl)-2-thiouracil | HCID 14338579 | — |
| Product | 2-[2-(5-Methyl-4-imidazolylmethylthio)ethylamino]-5-(3-pyridylmethoxy)-4-pyrimidone | HCID 23349282 | — |
Reaction Steps
Ethyl 3-pyridylmethoxyacetate is converted into 5-(3-pyridylmethoxy)-2-thiouracil by the general procedure of Example 1 (i). Substitution of 5-(3-pyridylmethoxy)-2-thiouracil for 5-(4-pyridylmethyl)-2-thiouracil in the general procedure of Example 1 gives 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(3-pyridylmethoxy)-4-pyrimidone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04216318 |
| Source dataset | uspto-grants-1980_08 |
| ORD ID | ord-9c148b54817249f8acd24873b858cfff |
| Source note | uspto-grants-1980_08 |