HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cysteamine Hydrochloride → 2-(3-Bromo-4-methyl-2-pyridylmethylthio)ethylamine dihydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cysteamine Hydrochloride | HCID 9082 | — |
| Reactant | (3-Bromo-4-methylpyridin-2-yl)methanol | HCID 23344241 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | 2-(3-Bromo-4-methyl-2-pyridylmethylthio)ethylamine dihydrobromide | HCID 23349285 | — |
Reaction Steps
A mixture of 3-bromo-2-hydroxymethyl-4-methylpyridine (5.8), cysteamine hydrochloride (3.5 g) and hydrobromic acid (48%, 50 ml) was refluxed for 6 hours and evaporated to dryness. The residue was crystallised from isopropanol/methanol to give 2-(3-bromo-4-methyl-2-pyridylmethylthio)ethylamine dihydrobromide (8.5 g) m.p. 203°-205°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04216318 |
| Source dataset | uspto-grants-1980_08 |
| ORD ID | ord-f5cc995a9627401b84218b5330678505 |
| Source note | uspto-grants-1980_08 |