HCID 178444822, compound → HCID 178444821, compound

HRID 1855936Notes

Reaction equation

HRID 1855936 reaction equation
[ClH:1].[CH2:2]([NH:8][C:9]([C:11]1[O:12][C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[N+:22]([O-])=O)=[CH:14][CH:15]=1)=[NH:10])[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]>[Pd].C(O)C>[ClH:1].[NH2:22][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[C:13]1[O:12][C:11]([C:9](=[NH:10])[NH:8][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])=[CH:15][CH:14]=1

Participants

4

Reactant 1

HCID 178444822HCID 178444822, compound

Product 1

HCID 178444821HCID 178444821, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of the compound of Example III (17 g, 0.048 mole), ethanol (250 ml), and 5% Pd/C-50% H2O (1.0 g) was subjected to hydrogenation at room temperature for 4 hours, using 6.0 psia H2 (theory: 5.9 psia H2). The catalyst was removed by filtration, the filtrate was diluted with anhydrous ether (1000 ml), and cooled. The product was collected by filtration and air dried; m.p. 148°-150°, yield: 15 g (97%).

Workup

  1. customThe catalyst was removed by filtration
  2. additionthe filtrate was diluted with anhydrous ether (1000 ml)
  3. temperaturecooled
  4. filtrationThe product was collected by filtration and air
  5. customdried

Sources & evidence

ORD record
ord-79ed8b9760f04f2fb0f7bb735966b32a
Source dataset
uspto-grants-1980_08
Patent number
US04217286

Reaction notes

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