HRID1855970

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7312

Diisopropylamine, N-(2-chloroethyl)-

C8H18ClN

HCID13195407

未命名化合物

结构：CC(C)N(CCC(C#N)c1ccc(-c2ccccc2)cc1)C(C)C

HCID14569341

未命名化合物

HCID23347210

未命名化合物

PRODUCTS

生成物

结构：CC(C)N(CCC(C#N)(CCN1CCC(c2ccccc2)CC1)c1cccc2ccccc12)C(C)C

HCID23347217

未命名化合物

PROCEDURE

实验过程

Substitution of equivalent quantities of α-[2-(diisopropylamino)ethyl]-α-(1-naphthyl)acetonitrile and 1-(2-chloroethyl)-4-phenylpiperidine for α-(4-biphenylyl)-α-[2-(diisopropylamino)ethyl]acetonitrile and 2-chloro-N,N-diisopropylethylamine called for in Example 2, Method B, respectively and substantial repetition of the procedure detailed therein, affords α-[2-(diisopropylamino)ethyl]-α-(1-naphthyl)-α-[2-(4-phenyl-1-piperidinyl)ethyl]acetonitrile.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2cf819f27a154c46b76ebc9dad5849d6
来源数据集: uspto-grants-1980_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04217306
来源说明: uspto-grants-1980_08

反应 SMILES

[CH:1]([N:4]([CH:20]([CH3:22])[CH3:21])[CH2:5][CH2:6][CH:7]([C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=[CH:12][CH:11]=1)[C:8]#[N:9])([CH3:3])[CH3:2].Cl[CH2:24][CH2:25][N:26]1[CH2:31][CH2:30][CH:29]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH2:28][CH2:27]1.C1(C2C=CC=CC=2)C=CC(C(CCN(C(C)C)C(C)C)C#N)=CC=1.ClCCN(C(C)C)C(C)C>>[CH:20]([N:4]([CH:1]([CH3:3])[CH3:2])[CH2:5][CH2:6][C:7]([C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=[CH:12][CH:11]=1)([CH2:24][CH2:25][N:26]1[CH2:27][CH2:28][CH:29]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH2:30][CH2:31]1)[C:8]#[N:9])([CH3:22])[CH3:21]