HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Diisopropylamino)ethyl chloride → alpha-[2-(Diisopropylamino)ethyl]-alpha-(1-naphthyl)-alpha-[2-(4-phenyl-1-piperidinyl)ethyl]acetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Diisopropylamino)ethyl chloride | HCID 7312 | — |
| Reactant | 1-(2-Chloroethyl)-4-phenylpiperidine | HCID 13195407 | — |
| Reactant | alpha-(4-Biphenylyl)-alpha-[2-(diisopropylamino)ethyl]acetonitrile | HCID 14569341 | — |
| Reactant | alpha-[2-(Diisopropylamino)ethyl]-alpha-(1-naphthyl)acetonitrile | HCID 23347210 | — |
| Product | alpha-[2-(Diisopropylamino)ethyl]-alpha-(1-naphthyl)-alpha-[2-(4-phenyl-1-piperidinyl)ethyl]acetonitrile | HCID 23347217 | — |
Reaction Steps
Substitution of equivalent quantities of α-[2-(diisopropylamino)ethyl]-α-(1-naphthyl)acetonitrile and 1-(2-chloroethyl)-4-phenylpiperidine for α-(4-biphenylyl)-α-[2-(diisopropylamino)ethyl]acetonitrile and 2-chloro-N,N-diisopropylethylamine called for in Example 2, Method B, respectively and substantial repetition of the procedure detailed therein, affords α-[2-(diisopropylamino)ethyl]-α-(1-naphthyl)-α-[2-(4-phenyl-1-piperidinyl)ethyl]acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04217306 |
| Source dataset | uspto-grants-1980_08 |
| ORD ID | ord-2cf819f27a154c46b76ebc9dad5849d6 |
| Source note | uspto-grants-1980_08 |