反应详情

69 Parts of α-(1-bromo-2-naphthyl)acetonitrile is stirred in 150 parts by volume of 50% sodium hydroxide and then 0.7 parts of benzyltriethylammonium chloride is added to the mixture. To this mixture is added slowly a solution of 41.82 parts of 2-chloro-N,N-diisopropylethylamine in 150 parts by volume of methylene chloride and the resulting mixture is stirred at room temperature for about 2 hours. Then, additional quantities of methylene chloride and water are added to the reaction mixture. The organic layer is then separated, dried over anhydrous sodium sulfate and concentrated to give α-(1-bromo-2-naphthyl)-α-[2-(diisopropylamino)ethyl]acetonitrile, as a solid. This compound is represented by the following structural formula ##STR34##

1. customThe organic layer is then separated
2. dry with materialdried over anhydrous sodium sulfate
3. concentrationconcentrated