Hydrochloric Acid → HCID 23347407, compound

HRID 1856012Notes

Reaction equation

HRID 1856012 reaction equation
[N:1]1([CH2:6][C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][C:8]=2[CH:16]([CH3:18])[CH3:17])[CH:5]=[CH:4][N:3]=[CH:2]1.[ClH:19]>C(O)C>[ClH:19].[N:1]1([CH2:6][C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][C:8]=2[CH:16]([CH3:18])[CH3:17])[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 194468UK 34787

Product 1

HCID 23347407HCID 23347407, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3-(Imidazol-1-ylmethyl)-2-isopropylindole (250 mg.) was dissolved in the minimum amount of ethanol (1.5 ml.) necessary to effect said solution with the aid of gentle warming. The latter alcoholic solution was then added dropwise to ethereal hydrogen chloride (15 ml.) to give a clear solution, which was thereafter allowed to stand for 10 minutes so as to permit precipitation of the desired hydrogen chloride acid addition salt to occur. The latter salt was recovered by means of suction filtration and recrystallized from ethyl acetate containing a trace of methanol to afford pure 3-(imidazol-1-ylmethyl)-2-isopropylindole hydrochloride. The yield of pure product (salt) melting at 187°-188° C. amounted to 230 mg. after first having been air dried to constant weight at 100° C. for a period of four hours.

Workup

  1. customto give a clear solution, which
  2. customprecipitation of the desired hydrogen chloride acid addition salt
  3. filtrationThe latter salt was recovered by means of suction filtration
  4. customrecrystallized from ethyl acetate containing a trace of methanol

Sources & evidence

ORD record
ord-50ce868af97849b3ad78607dab5e8921
Source dataset
uspto-grants-1980_08
Patent number
US04217357

Reaction notes

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