Hydrochloric Acid → Methyl 6-methylnicotinate

HRID 1856032Notes

Reaction equation

HRID 1856032 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.Cl.[CH3:12]O>>[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH3:12])=[O:7])=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 1378606-Methylnicotinic acid

Product 1

HCID 231548Methyl 6-methylnicotinate

Procedure

6-Methylnicotinic acid (0.1 mole) is refluxed in 100 ml. of methanol saturated with gaseous hydrogen chloride for 1 hour and then evaporated to dryness. The residue is stirred saturated aqueous sodium bicarbonate solution and the product is extracted into chloroform. The chloroform extract is dried and concentrated to dryness to give methyl 6-methylnicotinate.

Workup

  1. customevaporated to dryness
  2. extractionthe product is extracted into chloroform
  3. extractionThe chloroform extract
  4. customis dried
  5. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-631ed39422e8474ebaf2939cd2f33207
Source dataset
uspto-grants-1980_08
Patent number
US04217352

Reaction notes

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