HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 3-Azido-4-(2-trifluoroacetoxyethyl)azetidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Trifluoroacetic anhydride | HCID 9845 | — |
| Reactant | 3-Azido-4-(2-hydroxyethyl)-2-azetidinone | HCID 15592389 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Azido-4-(2-trifluoroacetoxyethyl)azetidin-2-one | HCID 54331764 | — |
Reaction Steps
Trifluoroacetic anhydride (0.2 mol) is added dropwise to an ice-cold, stirred solution of 3-azido-4-(2-hydroxyethyl)-azetidin-2-one (0.2 mol) and pyridine (0.21 mol) in methylene chloride (200 ml). The solution is stirred for 15 more min. at room temperature, then washed with water, dried with magnesium sulfate, and filtered. Evaporation of the methylene chloride under vacuum leaves 3-azido-4-(2-trifluoroacetoxyethyl)-azetidin-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04217453 |
| Source dataset | uspto-grants-1980_08 |
| ORD ID | ord-fcf150b556c84c8cbcc19bb3c44ee196 |
| Source note | uspto-grants-1980_08 |