反应详情

Trifluoroacetic anhydride (0.2 mol) is added dropwise to an ice-cold, stirred solution of 3-azido-4-(2-hydroxyethyl)-azetidin-2-one (0.2 mol) and pyridine (0.21 mol) in methylene chloride (200 ml). The solution is stirred for 15 more min. at room temperature, then washed with water, dried with magnesium sulfate, and filtered. Evaporation of the methylene chloride under vacuum leaves 3-azido-4-(2-trifluoroacetoxyethyl)-azetidin-2-one.

1. washat room temperature, then washed with water
2. dry with materialdried with magnesium sulfate
3. filtrationfiltered
4. customEvaporation of the methylene chloride under vacuum