反应详情

A mixture of benzyl 6-azido-3-toluenesulfonyloxy-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylate (0.1 mmol), N-methylpiperazine (0.11 mmol), triethylamine (1 mmol) and anhydrous dimethylformamide (1 ml) is allowed to stand at room temperature overnight. The mixture is diluted with ethylacetate, washed thoroughly with water and brine, dried over magnesium sulfate, and filtered. Evaporation of the solvent under vacuum provides benzyl 6-azido-3-(N-methylpiperazinyl)1-azabicyclo[3.2.0]-hept-2-en-7-one-2-carboxylate.

1. washwashed thoroughly with water and brine
2. dry with materialdried over magnesium sulfate
3. filtrationfiltered
4. customEvaporation of the solvent under vacuum