Iodoethane → HCID 23345728, compound

HRID 1856108Notes

Reaction equation

HRID 1856108 reaction equation
[I-:1].Br[C:3]1[C:8]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=2)=[CH:7][N+:6]([CH3:19])=[CH:5][C:4]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[CH2:26]([I:28])C>>[I-:28].[CH2:19]([N+:6]1[CH:7]=[C:8]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=2)[C:3]([I:1])=[C:4]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:5]=1)[CH3:26]

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 23345780HCID 23345780, compound

Product 1

HCID 23345728HCID 23345728, compound

Procedure

A 2 g. portion of the 4-bromopyridine intermediate of Example 9 was combined with 10 ml. of ethyl iodide and allowed to stand at room temperature for 3 days. Volatile materials were then evaporated under vacuum, and the solids were crystallized from chloroform-hexane, yield 0.25 g., m.p. 235°-238°. Analysis by nuclear magnetic resonance and mass spectrometry techniques identified the product as consisting of approximately 60 percent of the compound of Example 12, and approximately 40 percent of the compound of Example 13.

Workup

  1. customVolatile materials were then evaporated under vacuum
  2. customthe solids were crystallized from chloroform-hexane, yield 0.25 g

Sources & evidence

ORD record
ord-107359fc84e24707984ee78731afeeae
Source dataset
uspto-grants-1980_08
Patent number
US04218238

Reaction notes

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