HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 2-n-Tridecyl-5-[2-(1-methyl-5-nitroimidazol-2-yl)-vinyl]-1,3,4-thiadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 1-Methyl-5-nitro-1H-imidazole-2-carbaldehyde | HCID 78487 | — |
| Reactant | 2-Methyl-5-tridecyl-1,3,4-thiadiazole | HCID 23346374 | — |
| Catalyst | Zincchloride | HCID 3007855 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-n-Tridecyl-5-[2-(1-methyl-5-nitroimidazol-2-yl)-vinyl]-1,3,4-thiadiazole | HCID 53739186 | 56.6% |
Reaction Steps
8.45 g of 2-tridecyl-5-methyl-1,3,4-thiadiazole, 4.65 g of 1-methyl-5-nitroimidazole-2-carboxaldehyde and 0.5 g of zinc chloride are heated in 40 ml of acetic acid and 15 ml of acetic anhydride for 24 hours at reflux temperature. After the solvent has been removed, the residue is recrystallized from alcohol. 7.1 g of product is obtained, corresponding to 61% of the theory. The melting point is 91° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04218460 |
| Source dataset | uspto-grants-1980_08 |
| ORD ID | ord-0fb3f5fddbad49e8bda16a28667d452a |
| Source note | uspto-grants-1980_08 |