4-Chloropyridine → HCID 23346261, compound

HRID 1856197Notes

Reaction equation

HRID 1856197 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([SH:8])=[CH:4][CH:3]=1.[Cl:9][C:10]1[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=1>>[ClH:9].[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 122884-ChloropyridineHCID 677894-Fluorothiophenol

Product 1

HCID 23346261HCID 23346261, compoundYield 92.8%

Procedure

To 50.0 g of 4-fluorobenzenethiol cooled in an ice bath at 0° was slowly added 44.3 g of 4-chloropyridine. After several minutes, a vigorous reaction ensued with the formation of a white solid. The product was washed with ether and dried to yield 87.2 g (92.8%) of white powder, m.p. 217°-220°. Recrystallization from isopropanol gave white needles, m.p. 224°-226°.

Workup

  1. waitAfter several minutes
  2. customa vigorous reaction
  3. washThe product was washed with ether
  4. customdried

Sources & evidence

ORD record
ord-62b76aed11f94bb4a0aae45a3b0a5da2
Source dataset
uspto-grants-1980_08
Patent number
US04218455

Reaction notes

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