HCID 12515297, compound → HCID 23346267, compound

HRID 1856199Notes

Reaction equation

HRID 1856199 reaction equation
Cl.FC1C=CC(SC2CCNCC=2)=CC=1.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([S:23][C:24]2[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=2)=[CH:19][CH:18]=1.[H-].[Al+3].[H-].[H-]>CCOCC>[ClH:16].[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([S:23][C:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH:25]=2)=[CH:21][CH:22]=1

Participants

5

Reactant 3

HCID 12515297HCID 12515297, compoundHCID 21584524AluminiumhydrideHCID 23346235HCID 23346235, compound

Product 1

HCID 23346267HCID 23346267, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The product is prepared according to the procedure for the synthesis of 4-[(4-fluorophenyl)thio]-1,2,3,6-tetrahydropyridine hydrochloride by reducing 26.3 g of 4-[(4-chlorophenyl)thio]pyridine with aluminum hydride. The hydrochloride salt is generated in ether from the crude oil to afford a light tan powder, m.p. 174°-175° C.

Workup

  1. customThe product is prepared
  2. customto afford a light tan powder, m.p. 174°-175° C.

Sources & evidence

ORD record
ord-9ee0f930bd4b44a58a0b3bbdf5d980dc
Source dataset
uspto-grants-1980_08
Patent number
US04218455

Reaction notes

Loading…