HCID 23346120, compound → HCID 23346110, compound

HRID 1856216Notes

Reaction equation

HRID 1856216 reaction equation
[Cl:1][C:2]([F:25])([F:24])[C:3]([C:20]([Cl:23])([F:22])[F:21])([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[N:10]([C:14](=[O:19])[CH2:15][C:16](=O)[CH3:17])[CH2:9][CH2:8]2)[OH:4]>S(=O)(=O)(O)O>[Cl:23][C:20]([F:21])([F:22])[C:3]([C:5]1[CH:13]=[C:12]2[C:11]3=[C:7]([CH2:8][CH2:9][N:10]3[C:14](=[O:19])[CH:15]=[C:16]2[CH3:17])[CH:6]=1)([OH:4])[C:2]([Cl:1])([F:24])[F:25]

Participants

3

Reactant 1

HCID 23346120HCID 23346120, compound

Product 1

HCID 23346110HCID 23346110, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

By the method of Example 7, αα-bis(chlorodifluoromethyl)2,3-dihydro-1H-indole-5-methanol is converted to α,α-bis(chlorodifluoromethyl)-1-(1,3-dioxobutyl)-2,3-dihydro-1H-indole-5-methanol, which is cyclized by heating in sulfuric acid to give 1,2-dihydro-8-[2-chloro-2,2-difluoro-1-hydroxy-1-(chlorodifluoromethyl)ethyl]-6-methyl-4H-pyrrolo[3,2,1-ij]quinolin-4-one, m.p. 256°-257°.

Sources & evidence

ORD record
ord-ee259b44cdf24b82b60ae3c1975c815c
Source dataset
uspto-grants-1980_08
Patent number
US04218448

Reaction notes

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