HCID 23346120, compound → HCID 23346110, compound

Participants

Reaction Steps

By the method of Example 7, αα-bis(chlorodifluoromethyl)2,3-dihydro-1H-indole-5-methanol is converted to α,α-bis(chlorodifluoromethyl)-1-(1,3-dioxobutyl)-2,3-dihydro-1H-indole-5-methanol, which is cyclized by heating in sulfuric acid to give 1,2-dihydro-8-[2-chloro-2,2-difluoro-1-hydroxy-1-(chlorodifluoromethyl)ethyl]-6-methyl-4H-pyrrolo[3,2,1-ij]quinolin-4-one, m.p. 256°-257°.

Provenance & Evidence