Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 2-[2-(5-Methyl-4-imidazolylmethylthio)-ethylamino]-5-(2-phenylethyl)-4-pyrimidone dihydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2(1H)-Pyrimidinone | HCID 68401 | — |
| 반응물 | 4-(((2-Aminoethyl)thio)methyl)-5-methylimidazole | HCID 665568 | — |
| 반응물 | 5-(2-Phenylethyl)-2-thiouracil | HCID 12945971 | — |
| 반응물 | 5-Phenylethyl-2-methylthio-4-pyrimidone | HCID 12951508 | — |
| 생성물 | 2-[2-(5-Methyl-4-imidazolylmethylthio)-ethylamino]-5-(2-phenylethyl)-4-pyrimidone dihydrochloride | HCID 23346171 | — |
반응 단계
5-(2-Phenylethyl)-2-thiouracil (1.8 g) was converted into 5-phenylethyl-2-methylthio-4-pyrimidone (m.p. 160°-161° ex ethanol) by the method described in Example 1(i). Reaction of this pyrimidone (1.5) with 2-(5-methyl-4-imidazolylmethylthio)ethylamine (1.1 g) by the method described in Example 1(ii) gave an oil which was dissolved in 2 N hydrochloric acid, the solution evaporated to dryness and the residue recrystallised from methanol to give 2-[2-(5-methyl-4-imidazolylmethylthio)-ethylamino]-5-(2-phenylethyl)-4-pyrimidone dihydrochloride, m.p. 214°-218°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04218452 |
| 출처 데이터셋 | uspto-grants-1980_08 |
| ORD ID | ord-33d07fdff70d438db3e0a3c9177ae667 |
| 출처 메모 | uspto-grants-1980_08 |