反应详情

5-(2-Phenylethyl)-2-thiouracil (1.8 g) was converted into 5-phenylethyl-2-methylthio-4-pyrimidone (m.p. 160°-161° ex ethanol) by the method described in Example 1(i). Reaction of this pyrimidone (1.5) with 2-(5-methyl-4-imidazolylmethylthio)ethylamine (1.1 g) by the method described in Example 1(ii) gave an oil which was dissolved in 2 N hydrochloric acid, the solution evaporated to dryness and the residue recrystallised from methanol to give 2-[2-(5-methyl-4-imidazolylmethylthio)-ethylamino]-5-(2-phenylethyl)-4-pyrimidone dihydrochloride, m.p. 214°-218°.

1. customgave an oil which
2. customthe solution evaporated to dryness
3. customthe residue recrystallised from methanol