Hydrochloric Acid → HCID 23346166, compound

HRID 1856263Notes

Reaction equation

HRID 1856263 reaction equation
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([CH2:6][C:7]2[C:8](=[O:15])[NH:9][C:10](SC)=[N:11][CH:12]=2)=[CH:4][CH:3]=1.[S:18]1[CH:22]=[CH:21][N:20]=[C:19]1[CH2:23][S:24][CH2:25][CH2:26][NH2:27].Cl>>[ClH:1].[S:18]1[CH:22]=[CH:21][N:20]=[C:19]1[CH2:23][S:24][CH2:25][CH2:26][NH:27][C:10]1[NH:9][C:8](=[O:15])[C:7]([CH2:6][C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:17][CH:16]=2)=[CH:12][N:11]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 129234032-[(Thiazol-2-yl)methylthio]ethylamineHCID 129459805-(4-Chlorobenzyl)-2-methylthiopyrimid-4-one

Product 1

HCID 23346166HCID 23346166, compound

Procedure

An intimate mixture of 5-(4-chlorobenzyl)-2-methylthio-4-pyrimidone (1.36 g) and 2-(2-thiazolylmethylthio)ethylamine (0.9 g) was heated at 130°-135° for 31/2 hours. After cooling the reaction mixture was treated with 2 N hydrochloric acid. Evaporation to dryness followed by recrystallisation from isopropanol/methanol gave 2-[2-(2-thiazolyl-methylthio)ethylamino]-5-(4-chlorobenzyl)-4-pyrimidone monohydrochloride, m.p. 172.5°-174.5°.

Workup

  1. temperaturewas heated at 130°-135° for 31/2 hours
  2. temperatureAfter cooling the reaction mixture
  3. customEvaporation to dryness
  4. customfollowed by recrystallisation from isopropanol/methanol

Sources & evidence

ORD record
ord-b3f5d091314641a28d7890fba66496ba
Source dataset
uspto-grants-1980_08
Patent number
US04218452

Reaction notes

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