Hydrochloric Acid → N-(2,6-Dimethyl-4-propoxyphenyl)alaninamide

HRID 1856296Notes

Reaction equation

HRID 1856296 reaction equation
[NH2:1][CH:2]([CH3:19])[C:3]([NH:5][C:6]1[C:11]([CH3:12])=[CH:10][C:9]([O:13][CH2:14][CH2:15][CH2:16]C)=[CH:8][C:7]=1[CH3:18])=[O:4].Cl>>[NH2:1][CH:2]([CH3:19])[C:3]([NH:5][C:6]1[C:11]([CH3:12])=[CH:10][C:9]([O:13][CH2:14][CH2:15][CH3:16])=[CH:8][C:7]=1[CH3:18])=[O:4]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 12546854HCID 12546854, compound

Product 1

HCID 12546856N-(2,6-Dimethyl-4-propoxyphenyl)alaninamide

Procedure

This compound was prepared in the same manner as 2-amino-4'-butoxy-2',6'-dimethylpropionanilide of Example 9D. The yield of crude base was 94% which was converted to the hydrochloride and recrystallized from absolute alcohol-ether; m.p. 226°-227° C. Calcd. for C14H23ClN2O2 : C 58.6, H 8.08, O 11.2. Found: C 58.8, H 8.08, O 11.2.

Workup

  1. customrecrystallized from absolute alcohol-ether

Sources & evidence

ORD record
ord-55cbd6a42ff24863b0dad48a8c3c8395
Source dataset
uspto-grants-1980_08
Patent number
US04218477

Reaction notes

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