2,6-Diethylaniline → HCID 12546827, compound

HRID 1856302Notes

Reaction equation

HRID 1856302 reaction equation
[CH2:1]([C:3]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][CH3:11])[C:4]=1[NH2:5])[CH3:2].[Br:12][CH:13]([CH3:17])[C:14](Br)=[O:15]>>[Br:12][CH:13]([CH3:17])[C:14]([NH:5][C:4]1[C:6]([CH2:10][CH3:11])=[CH:7][CH:8]=[CH:9][C:3]=1[CH2:1][CH3:2])=[O:15]

Participants

3

Reactant 2

HCID 113692,6-DiethylanilineHCID 79047Propanoyl bromide, 2-bromo-

Product 1

HCID 12546827HCID 12546827, compoundYield 80%

Procedure

Following the procedure described in Example 8A using 2,6-diethylaniline and 2-bromopropionyl bromide the desired intermediate was obtained in 80% yield. Recrystallized from abs. methanol it melted at 197°-199° C. Calcd.: C 54.9, H 6.38, N 4.93, Br 28.1. Found: C 54.8, H 6.19, N 5.02, Br 27.9.

Workup

  1. customwas obtained in 80% yield
  2. customRecrystallized from abs

Sources & evidence

ORD record
ord-d5a8bfcacaf943b9aafa2573a6ac46e5
Source dataset
uspto-grants-1980_08
Patent number
US04218477

Reaction notes

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