Trifluoroacetic acid → HCID 23344912, compound

HRID 1856411Notes

Reaction equation

HRID 1856411 reaction equation
[CH3:1][CH:2]([CH3:30])[CH:3]([CH2:11][CH:12]([S:20][NH:21][C:22](=[O:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:4]([O:6]C(C)(C)C)=[O:5].FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:1][CH:2]([CH3:30])[CH:3]([CH2:11][CH:12]([S:20][NH:21][C:22](=[O:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[C:4]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23344900HCID 23344900, compound

Product 1

HCID 23344912HCID 23344912, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 21.1 mm t-butyl 3-methyl-2-(3-phenyl-2-benzamidothiopropyl)butyrate in 5 ml of methylene chloride is added 15 ml of trifluoroacetic acid. The solution is stirred at room temperature for approximately 21/2 hours. The solvent is then evaporated, yielding 3-methyl-2-(3-phenyl-2-benzamidothiopropyl)butyric acid.

Workup

  1. customThe solvent is then evaporated

Sources & evidence

ORD record
ord-340f8a1d915d4e46babe3cb19811b7ba
Source dataset
uspto-grants-1980_08
Patent number
US04219497

Reaction notes

Loading…