1-Phenylpiperazine → HCID 23345046, compound

HRID 1856460Notes

Reaction equation

HRID 1856460 reaction equation
[CH3:1][CH:2]([O:6][C:7]1[CH:8]=[C:9]([CH:15]2[CH2:19][NH:18][C:17](=[O:20])[CH2:16]2)[CH:10]=[CH:11][C:12]=1[O:13][CH3:14])[CH:3]1[O:5][CH2:4]1.[C:21]1([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>C(O)C>[CH3:14][O:13][C:12]1[CH:11]=[CH:10][C:9]([CH:15]2[CH2:19][NH:18][C:17](=[O:20])[CH2:16]2)=[CH:8][C:7]=1[O:6][CH:2]([CH3:1])[CH:3]([OH:5])[CH2:4][N:30]1[CH2:31][CH2:32][N:27]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:28][CH2:29]1

Participants

4

Reactant 2

HCID 70961-PhenylpiperazineHCID 23345056HCID 23345056, compound

Product 1

HCID 23345046HCID 23345046, compoundYield 68%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In accordance with the process set forth in Example 1, 10 mmol of 4-[3-(1-methyl-2,3-epoxypropoxy)-4-methoxyphenyl]-2-pyrrolidone and 10 mmol of 1-phenylpiperazine (95% strength) produce, in a 68% yield, 4-{4-methoxy-3-[3-(4-phenylpiperazin-1-yl)1-methyl-2-hydroxypropoxy]phenyl}-2-pyrrolidone, m.p. 116°-118° (ethanol).

Sources & evidence

ORD record
ord-b1bf25d9348c4624bf53a971a2a8897c
Source dataset
uspto-grants-1980_08
Patent number
US04219551

Reaction notes

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