関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| 反応物 | 6-Ethoxypyridin-3-amine | HCID 3040301 | — |
| 生成物 | Diethyl 6-ethoxy-3-pyridylaminomethylenemalonate | HCID 621746 | 93.7% |
反応手順
A mixture of 2- ethoxy-5-aminopyridine (2.89 g, 20.9 mmol) and diethyl ethoxymethylenemalonate (4.23 mL, 20.9 mmol) was heated at 130° C. for 4.5 hours. While warm, the mixture was evacuated. After cooling, the product was triturated with 2:1 hexanes:ether and collected to afford 6.04 g of diethyl (2-ethoxy-5-pyridylaminomethylene)malonate as a beige solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06143760 |
|---|
| 出典データセット | uspto-grants-2000_11 |
|---|
| ORD ID | ord-d111c43aa9f24a44a6cac65d1adbe8c1 |
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| 出典メモ | uspto-grants-2000_11 |
|---|
