反应详情

温度

130 °C

A mixture of 2- ethoxy-5-aminopyridine (2.89 g, 20.9 mmol) and diethyl ethoxymethylenemalonate (4.23 mL, 20.9 mmol) was heated at 130° C. for 4.5 hours. While warm, the mixture was evacuated. After cooling, the product was triturated with 2:1 hexanes:ether and collected to afford 6.04 g of diethyl (2-ethoxy-5-pyridylaminomethylene)malonate as a beige solid.

1. temperatureWhile warm
2. customthe mixture was evacuated
3. temperatureAfter cooling
4. customthe product was triturated with 2:1 hexanes
5. customether and collected